Publications
2025
S. Huayamares, L. Lian, R. Rab, Y. Hou, A. Radmand, H. Kim, R. Zenhausern, B. Achyut, M. Gilbert-Ross, M. Lokugamage, D. Loughrey, H. Peck, E. Echeverri, A. Da Silva, A. Shajii, A. Li, K. Tiegreen, P. Santangelo, E. Sorscher. 2025. Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses. Nature Communications. In press.
2024
J. Koo, C-S. Seong, R.E. Parker, A. Herrera, B. Dwivedi, R.A. Arthur, A.R. Dinasarapu, H.R. Johnston, H. Claussen, C. Tucker-Burden, S.S. Ramalingam, H. Fu, W. Zhou, A.I. Marcus, M. Gilbert-Ross. 2024. Live-cell invasive phenotyping uncovers ALK2 as a therapeutic target in LKB1-mutant lung cancer. Cancer Res. 84(22): 3761–3771.
R. Sharma, P. Shriwas, M. Labdhi, J. Mouw, J. Koo, G. Joseph, M. Behera, S-Y. Sun, M. Gilbert-Ross, T. Leal, A.I. Marcus, M. Shanmugam. 2024. Intra-tumoral YAP and TAZ heterogeneity drive collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981. iScience 27(11): 111133.
2023
J. Koo, C.S. Seong, R.E. Parker, B. Dwivedi, R.A. Arthur, A.R. Dinasarapu, H.R. Johnston, H. Claussen, C. Tucker-Burden, S.S. Ramalingam, H. Fu, W. Zhou, A.I. Marcus, M. Gilbert-Ross. 2023. Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer. bioRxiv preprint.
R.E. Parker, J. Koo, B. Dwivedi, A.I. Marcus, M. Gilbert-Ross. 2023. Defining the role of PER1 and circadian rhythm dysregulation in KRAS/LKB1-mutant lung adenocarcinoma. Molecular Cancer Research 21 (5 supplement): A027.
R. Rab, A. Ehrhardt, B.R. Achyut, D. Joshi, M. Gilbert-Ross, C. Huang, K. Floyd, A.V. Borovjagin, W.B. Parker, E.J. Sorscher, J. S. Hong. 2023. Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient-derived xenografts. Cancer Reports 6(2): 1–9.
C-S. Seong, C. Huang, A.C. Boese, Y. Hou, J. Koo, J.K. Mouw, M. Rupji, G. Joseph; H.R. Johnston, H. Claussen, J.M. Switchenko, M. Behera, M. Churchman, J.M. Kolesar, S.M. Arnold, K. Kerrigan, W. Akerley, H. Colman, M.A. Johns, C. Arciero, W. Zhou, A.I. Marcus, S.S. Ramalingam, H. Fu, M. Gilbert-Ross. 2023. Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis. bioRxiv preprint.
2022
J. Koo, C-S. Seong, B. Dwivedi, C. Tucker-Burden, A.I. Marcus, M. Gilbert-Ross. 2022. Targeting bone morphogenetic protein 6 as a therapeutic target for LKB1-inactivated lung cancer. Cancer Research 82(12 supplement): 1036.
Y. Fan, R. Jin, X. Liu, Y. Liu, C. Huang, M. Gilbert-Ross, A. Marcus, W. Zhou. 2022. Developing a sex-biased model for LKB1-mutant lung adenocarcinoma. Cancer Research 82(12 supplement): 936.
2021
T.K. Owonikoko. B. Dwivedi, Z. Chen, C. Zhang, B. Barwick, V. Ernani, G. Zhang, M. Gilbert-Ross, J. Carlisle. F.R. Khuri, W.J. Curran, A.A. Ivanov, H. Fu, S. Lonial, S.S. Ramalingam, S-Y. Sun, E.K. Waller, G.L. Sica. 2021. YAP1 expression in SCLC defines a distinct subtype with t-cell–inflamed phenotype. Journal of Thoracic Oncology 16(3): 464–476.
R. Jin, B. Liu, X. Liu, Y. Fan, W. Peng, C. Huang, A. Marcus, G. Sica, M. Gilbert-Ross, Y. Liu, W. Zhou. 2021. Leflunomide suppresses the growth of LKB1-inactivated tumors in the immune-competent host and attenuates distant cancer metastasis. Mol Cancer Ther. 20(2): 274–283.
B. Rackley, C.S. Seong, E. Kiely, R.E. Parker, M. Rupji, B. Dwivedi, J.M. Heddleston, W. Giang, N. Anthony, T-L. Chew, M. Gilbert-Ross. 2021. The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo. Commun Biol 4(142).
E. Kiely, M. Gilbert-Ross. 2021. The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen. MicroPubl Biol. 1–9.
B. Rackley, C-S. Seong, E. Kiely, R.E. Parker, M. Rupji, B. Dwivedi, J.M. Heddleston, W. Giang, N. Anthony, T-L. Chew, M. Gilbert-Ross. 2021. The level of oncogenic Ras controls the malignant transformation of Lkb1 mutant tissue in vivo. Commun Biol. 4(1): 142.
2020
T.K. Owonikoko, B. Dwivedi, Z. Chen, C. Zhang, B. Barwick, M. Gilbert-Ross, V. Ernani, B. Barwick, G. Zhang, J.W. Carlisle, F.R. Khuri, W.J. Curran, S. Lonial, S.S. Ramalingam, S-Y. Sun, E.K. Waller, and G. Sica. 2020. YAP1 positive small-cell lung cancer subtype is associated with the T-cell inflamed gene expression profile and confers good prognosis and long term survival. Journal of Clinical Oncology 38(15 supplement).
B.B. Rackley, C-S. Seong, M. Gilbert-Ross. 2020. High-level expression of oncogenic KRAS is required to transform LKB1 mutant tissue in vivo. Molecular Cancer Research 18(5 supplement): B04.
D. Hampton, B. Achyut, C. Tucker-Burden, A. Marcus, M. Gilbert-Ross, D. Schuster. 2020. Radionuclide Therapy of Breast Cancer in Mice with Tritiated 2-Deoxy-D-Glucose. Journal of Nuclear Medicine 61(supplement 1): 1225.
B.B. Rackley, E. Kiely, C.S. Seong, M. Rupji, M. Gilbert-Ross. 2020. Oncogenic Ras cooperates with knockdown of the tumor suppressor Lkb1 by RNAi to override organ size limits in Drosophila wing tissue. MicroPubl Biol.
W.B. Parker, P.W. Allan, W.R. Waud, J. Hong, M. Gilbert-Ross, B.R. Achyut, D. Joshi, T. Behbahani, R. Rab, S.E. Ealick, E.J. Sorscher. 2020. The use of Trichomonas vaginalis purine nucleoside phosphorylase to activate fludarabine in the treatment of solid tumors. Cancer Chemother Pharmacol. 85: 573–583.
2019
R. Jin, X. Liu, W. Peng, Y. Fan, B. Liu, S. Yang, C-G. Xing, M. Gilbert-Ross, A. Marcus, W. Zhou. 2019. Leflunomide inhibits the growth of LKB1-inactivated tumors in both xenograft and immunocompetent genetically engineered mouse models. Cancer Research 79(13 supplement): 4838.
L.J. Burton, J. Koo, C. Tucker-Burden, W. Zhou, M. Gilbert-Ross, C. Huang, G. Sica, A. Marcus. 2019. Isolation of circulating tumors cells from genetically engineered mouse models of lung adenocarcinoma. Cancer Research 79 (13 supplement): 865.
2018
A.M. Richardson, L.S. Havel, A.E. Koyen, J.M. Konen, J. Shupe, W.G. Wiles, W.D. Martin, H.E. Grossniklaus, G. Sica, M. Gilbert-Ross, A.I. Marcus. 2018. Vimentin is required for lung adenocarcinoma metastasis via heterotypic tumor cell–cancer-associated fibroblast interactions during collective invasion. Clin Cancer Res. 24(2): 420–432.
2017
R. Li, C. Ding, J. Zhang, M. Xie, D. Park, Y. Ding, G. Chen, G. Zhang, M. Gilbert-Ross, W. Zhou, A.I. Marcus, S-Y. Sun, Z.G. Chen, G.L. Sica, S.S. Ramalingam, A.T. Magis, H. Fu, F.R. Khuri, W.J. Curran, T.K. Owonikoko, D.M. Shin, J. Zhou, X. Deng. 2017. Modulation of bax and mTOR for cancer therapeutics. Cancer Res. 77(11): 3001–3012.
C. Wei, A. Achreja, J. Konen, G. Sica, M. Gilbert-Ross, D. Nagrath, A. Marcus, M. Shanmugam. 2017. GLUT4 exhibits a non-canonical role of regulating lung cancer metastasis. Cancer Research 77(13 supplement): 4904.
R. Li, C. Ding, J. Zhang, M. Xie, D. Park, Y. Ding, G. Chen, G. Zhang, M. Gilbert-Ross, W. Zhou, A.I. Marcus, S.Y. Sun, Z.G. Chen, G.L. Sica, S.S. Ramalingam, A.T. Magis, H. Fu, F.R. Khuri, W.J. Curran, T.K. Owonikoko, D.M. Shin, J. Zhou, X. Deng. 2017. Modulation of Bax and mTOR for Cancer Therapeutics. Cancer Res. 77(11): 3001–3012.
M. Gilbert-Ross, J. Konen, J. Koo, J. Shupe, B.S. Robinson, W.G Wiles IV, C. Huang, W.D. Martin, M. Behera, G.H. Smith, C.E. Hill, M.R. Rossi, G.L. Sica, M. Rupji, Z. Chen, J. Kowalski, A.L. Kasinski, S.S. Ramalingam, H. Fu, F.R. Khuri, W. Zhou, and A.I. Marcus. 2017. Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma. JCI Insight 2(5): e90487.
2016
A.M. Salgueiro, M. Gilbert-Ross, L.S. Havel, J. Shupe, A.E. Koyen, H.E. Grossniklaus, G. Sica, A.I. Marcus. 2016. Beyond EMT: Vimentin function in lung cancer metastasis. Cancer Research 76(15 supplement): C24.
M. Gilbert-Ross, J. Konen, J. Koo, J. Shupe, G.L. Sica, Z. Chen, B.S. Robinson, M. Behera, M.R. Rossi, G.H. Smith. 2016. Developing a personalized anti-metastatic therapy to treat KRAS, LKB1-mutant lung adenocarcinoma. Cancer Research 76(14 supplement): LB348.
M. Gilbert-Ross, J. Konen, J. Shupe, J. Koo, G.L. Sica, S.S. Ramalingam, H. Fu, F.R. Khuri, W. Zhou, A.I. Marcus. 2016. An early treatment window to target FAK-dependent collective invasion in Lkb1-mutant lung adenocarcinoma. Cancer Research 76(7 supplement): B45.
A.M. Salgueiro, L.S. Havel, J. Shupe, A.E. Koyen, H.E. Grossniklaus, G. Sica, M. Gilbert-Ross, A.I. Marcus. 2016. Beyond EMT: vimentin function in lung cancer metastasis. Cancer Research 76 (15 supplement): C24.
R. Commander, Y. Hou, J. Konen, S. Wilkinson, M. Gilbert-Ross, L. Cooper, A.I. Marcus. 2016. Defining the invasive biology of clinically relevant LKB1 mutations in lung cancer. Molecular Biology of the Cell 27.
2015
A.M. Salgueiro, M. Gilbert-Ross, L.S. Havel, J. Shupe, A.I. Marcus. 2015. More than a biomarker: studying the role of vimentin in lung cancer metastasis. Cancer Research 75(15 supplement): 2290.
M. Gilbert-Ross, A.I. Marcus, Wei Zhou. 2015. RhoA, a novel tumor suppressor or oncogene as a therapeutic target? Genes Dis. 2(1): 2–3.
2013
E.R. Kline, J. Shupe, M. Gilbert-Ross, W. Zhou, A.I. Marcus. 2013. LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence. Cell Biology 288(24): P17663–17674
2011
M.M. Gilbert, M. Tipping, A. Veraksa, K.H. Moberg. 2011. A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie. Developmental Cell. 20(5): P700–712
2009
M.M. Gilbert, B.S. Robinson, K.H. Moberg. 2009. Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in drosophila imaginal disc tumors. PLOS One 4(9): e7039.
M.M. Gilbert, C.K. Beam, B.S. Robinson, K.H. Moberg. 2009. Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor. PLOS One 4(9): e7083.
S.C. Nicholson, M.M. Gilbert, B.N. Nicolay, M.V. Frolov, K.H. Moberg. 2009. The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues. Current Biology 19(18): p1503–1510.
2006
M.M. Gilbert, K.H. Moberg. 2006. ESCRTing cell proliferation off the beaten path: unexpected lessons from the Drosophila eye. Cell Cycle 5(3), 283–287.
2005
M.M. Gilbert, B.K. Weaver, J.P. Gergen, N.C. Reich. 2005. A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation. Mechanisms of Development 122(7–8): 939–948.